[The humoral depressor system function in rheumatic heart defects with arterial hypertension]

A study of 115 patients with rheumatic heart disease associated with arterial hypertension revealed significant changes of functioning of depressor kallikrein-kinin system of the kidneys and blood. The period of formation of arterial hypertension is already distinguished by an exhaustion of the depressor systems manifested in a marked reduction of the kallikrein excretion in response to physical loads and a reduction of the extracellular volume deteriorating in the course of stabilization of arterial hypertension.