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Updated: May 20, 2026

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Highly efficient remote controlled release system based on light-driven DNA nanomachine functionalized mesoporous

Yongqiang Wen1, Liping Xu, Wenqian Wang

  • 1Research Center for Bioengineering & Sensing Technology, University of Science and Technology Beijing, Beijing 100083, China. wyq_wen@iccas.ac.cn

Nanoscale
|July 4, 2012
PubMed
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Researchers developed a smart DNA nanomachine using azobenzene groups that changes shape with light. This allows for highly efficient controlled release applications, demonstrated using fluorescence resonance energy transfer (FRET).

Area of Science:

  • Molecular nanotechnology
  • Biomolecular engineering
  • Photochemistry

Background:

  • DNA nanotechnology enables the construction of complex molecular machines.
  • Azobenzene derivatives are known photoswitchable molecules responsive to light.
  • Mesoporous silica offers a versatile platform for nanomaterial immobilization.

Purpose of the Study:

  • To design and investigate an intelligent photoswitchable single-molecule nanomachine.
  • To utilize DNA hairpin-loop structures for light-controlled conformational changes.
  • To achieve highly efficient controlled release using photo-induced DNA transformations.

Main Methods:

  • Incorporation of azobenzene groups into DNA sequences to create photoswitchable elements.
  • Utilizing fluorescence resonance energy transfer (FRET) to study molecular conformational changes.

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Last Updated: May 20, 2026

Predicting Gene Silencing Through the Spatiotemporal Control of siRNA Release from Photo-responsive Polymeric Nanocarriers
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Published on: July 21, 2017

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10:07

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Published on: October 8, 2021

  • Immobilizing the DNA nanomachine onto the surface of mesoporous silica.

    • Main Results:

    • Successful design of a single-molecule nanomachine with a DNA hairpin-loop structure.
    • Demonstration of photo-induced conformational transformation of the DNA nanomachine upon light irradiation.
    • Realization of highly efficient controlled release facilitated by the light-triggered DNA conformational changes.

    Conclusions:

    • The developed DNA nanomachine exhibits intelligent photoswitchable behavior.
    • The integration of azobenzene groups enables light-responsive conformational control.
    • This platform holds potential for advanced controlled release systems and molecular nanotechnology.