Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in metabolism during toxicity tests.

T Green1

  • 1ICI Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Longitudinal Improvements in Clinical Outcomes for Children with Cystic Fibrosis Aged Six Years.

Irish medical journal·2025
Same author

Participatory arts, refugees and mental health.

Perspectives in public health·2024
Same author

Spin Echo, Fidelity, and the Quantum Critical Fan in TmVO_{4}.

Physical review letters·2024
Same author

Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

Physical review letters·2024
Same author

Lawson Criterion for Ignition Exceeded in an Inertial Fusion Experiment.

Physical review letters·2022
Same author

A follow-up on quantitative and qualitative olfactory dysfunction and other symptoms in patients recovering from COVID-19 smell loss.

Rhinology·2022
Same journal

Berberine Hydrochloride Induces Apoptosis in Triple-Negative Breast Cancer Cells Through Modulation of the sirtuin/p65 Signaling Axis.

Xenobiotica; the fate of foreign compounds in biological systems·2026
Same journal

Computational analysis of dual targeting of β<sub>1</sub>-adrenergic and AT<sub>1</sub> receptors by bisoprolol fumarate and candesartan cilexetil for hypertensive modulation.

Xenobiotica; the fate of foreign compounds in biological systems·2026
Same journal

Total saponins from ginseng stems and leaves antagonise acute lead-cadmium co-exposure-induced oxidative liver damage in mice via the Keap1/Nrf2 signalling pathway.

Xenobiotica; the fate of foreign compounds in biological systems·2026
Same journal

Intestinal deglycosylation activates saikosaponins as potent, selective UGT2B7/2B15 inhibitors: structural basis and implications for herb-drug interactions.

Xenobiotica; the fate of foreign compounds in biological systems·2026
Same journal

Tetrahydrouridine pre-treatment increases tissue exposure of <sup>14</sup>C-decitabine in mice.

Xenobiotica; the fate of foreign compounds in biological systems·2026
Same journal

Modulatory role of fucoidan against monosodium glutamate-induced reproductive and hepatorenal toxicity in adult male rats.

Xenobiotica; the fate of foreign compounds in biological systems·2026
See all related articles

Animal metabolism in toxicity studies can change with age or chemical exposure. Monitoring these metabolic shifts is crucial for understanding toxicity mechanisms and observed effects, especially in young or developing animals.

Area of Science:

  • Toxicology
  • Pharmacokinetics
  • Biochemistry

Background:

  • Metabolism in rodent chronic toxicity studies can be influenced by animal age, chemical interactions, or toxic properties.
  • Developing animals, particularly fetuses and newborns, have immature metabolic enzyme systems that mature over the first 30 days of life.
  • Current regulatory practices for pesticide and industrial chemical evaluations typically utilize young adult animals with fully developed enzyme systems, omitting age-specific metabolic considerations.

Purpose of the Study:

  • To highlight the variability of animal metabolism during chronic toxicity studies.
  • To emphasize the importance of considering age-related metabolic differences in toxicity assessments.
  • To advocate for the monitoring of metabolic changes in specific cases to elucidate toxicity mechanisms.

Related Experiment Videos

Main Methods:

  • Discussion of relevant metabolic parameters to be monitored in toxicity studies.
  • Review of existing literature on age-dependent metabolism in toxicological evaluations.
  • Analysis of case examples illustrating the impact of metabolic alterations on toxicity outcomes.

Main Results:

  • Metabolic enzyme activity in rodents undergoes significant changes during early life and can be altered by chemical exposure.
  • Lack of regulatory requirements for monitoring metabolism in young or aged animals during chronic toxicity studies.
  • Metabolic variations can directly influence the toxicological profile and the development of adverse effects, including tumors.

Conclusions:

  • Monitoring metabolic changes, even without regulatory mandates, is valuable for a comprehensive understanding of chemical toxicity.
  • Age-related metabolic differences in animals are a critical factor in interpreting toxicity study results.
  • Understanding metabolic variability is essential for accurate risk assessment of pesticides and industrial chemicals.