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Reduced GABA concentration in attention-deficit/hyperactivity disorder

Richard A E Edden1, Deana Crocetti, He Zhu

  • 1Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. raee2@jhu.edu

Archives of General Psychiatry
|July 4, 2012
PubMed
Summary

Children with attention-deficit/hyperactivity disorder (ADHD) show reduced levels of gamma-aminobutyric acid (GABA), a key inhibitory neurotransmitter. This finding supports a GABAergic deficit in ADHD, impacting cortical inhibition.

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