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[Biologicals 2012].

¹Interdisziplinäre Diagnostik und Therapie in der Akademie für Manuelle Medizin an der Westfälischen Wilhelms-Universität Münster, Von-Esmarch-Str. 50, 48149, Münster, Deutschland. gaubitz@uni-muenster.de

|July 4, 2012

Summary

This summary is machine-generated.

Biological therapies for rheumatic diseases offer improved outcomes and remission. While generally safe, they slightly increase infection risk, necessitating careful screening before treatment.

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Area of Science:

Rheumatology
Immunology
Pharmacology

Context:

Biological therapies have transformed rheumatic disease management.
Increased patient and physician expectations for treatment efficacy.
Availability of multiple biologic agents targeting various inflammatory pathways.

Purpose:

To review the efficacy and safety of biological therapies in rheumatic diseases.
To highlight therapeutic aims including remission and halting structural damage.
To discuss available biological agents and their targets.

Summary:

Five TNF-α inhibitors and four other biologics targeting IL-1, IL-6, B-lymphocytes, and cell-cell interactions were available by 2012.
Safety data from studies and registries are reassuring.
The primary side effect is a slightly increased risk of infections, particularly in the first year.
No increased cancer risk, except possibly for skin cancer, has been observed with anti-TNF-α therapy.

Impact:

Biologicals provide effective treatment options for rheumatic diseases, enabling remission and preventing structural damage.
Careful patient selection and monitoring are crucial due to potential side effects like infections.
Pre-treatment screening for tuberculosis and vaccinations are essential for safe biological therapy.