Related Experiment Video

Updated: May 20, 2026

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection
09:11

Imaging of In Situ Interferon Gamma Production in the Mouse Spleen following Listeria monocytogenes Infection

Published on: July 16, 2019

Marked elevation of interferon-γ in acute focal bacterial nephritis

Yasuyo Kashiwagi, Hisashi Kawashima, Shonosuke Nara

    Clinical and Experimental Nephrology
    |July 4, 2012
    PubMed

    Insights

    Acute focal bacterial nephritis (AFBN) in children is linked to higher interferon-gamma levels. This suggests localized kidney infection and potential local immune response.

    Area of Science:

    • Pediatric Nephrology
    • Infectious Diseases
    • Immunology

    Background:

    • Acute focal bacterial nephritis (AFBN) is a localized bacterial infection of the kidney parenchyma.
    • Understanding the immune response in AFBN is crucial for diagnosis and treatment.
    • Cytokine profiles can indicate the nature and location of infections.

    Discussion:

    • Serum cytokine levels, including interleukins and TNF-α, showed no significant difference between AFBN patients and controls.
    • A notable increase in serum interferon-gamma (IFN-γ) was observed in children with AFBN compared to the control group.
    • This finding suggests that IFN-γ may play a specific role in the localized immune response to bacterial kidney infections.

    Key Insights:

    • Elevated serum interferon-gamma levels are a potential biomarker for acute focal bacterial nephritis in children.
    • The study indicates that the immune response in AFBN might be localized, with IFN-γ being a key mediator.
    • This research contributes to understanding the specific cytokine involvement in pediatric kidney infections.

    Outlook:

    • Further research could explore the local production of IFN-γ within the renal parenchyma in AFBN.
    • Investigating therapeutic strategies targeting IFN-γ in AFBN could be a future direction.
    • Longitudinal studies may clarify the role of IFN-γ in the resolution and long-term outcomes of AFBN.

    More Related Videos

    Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses10:10

    Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

    Published on: November 16, 2016

    Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α08:26

    Development and Validation of an Ultrasensitive Single Molecule Array Digital Enzyme-linked Immunosorbent Assay for Human Interferon-α

    Published on: June 14, 2018

    Related Concept Videos

    Acute Pyelonephritis I: Introduction01:27

    Acute Pyelonephritis I: Introduction

    Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
    Acute Inflammation III: Local and Systemic Effects01:25

    Acute Inflammation III: Local and Systemic Effects

    Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
    Acute Inflammation I: Inflammatory Response01:26

    Acute Inflammation I: Inflammatory Response

    Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...
    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
    Immune Response Against Viral Pathogens01:29

    Immune Response Against Viral Pathogens

    The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
    NK Cells
    NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
    Acute Inflammation II: Cellular Phase01:26

    Acute Inflammation II: Cellular Phase

    The cellular phase of acute inflammation is a tightly orchestrated sequence of events that recruits leukocytes, primarily neutrophils, to sites of tissue injury or infection. Following the initial vascular changes, this phase ensures effective immune cell migration, activation, and function at the affected site to eliminate pathogens and initiate tissue repair.Leukocyte Recruitment CascadeLeukocyte recruitment happens in four steps: margination, adhesion, transmigration, and chemotaxis. Reduced...