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Peripheral oedema as a side-effect of fluticasone
1Department of Anaesthetics, Mayday University Hospital, London, UK. alice_e_myers@hotmail.com
BMJ Case Reports
|July 4, 2012
Summary
A rare side effect of inhaled fluticasone (an asthma medication) is peripheral oedema. This case highlights the importance of considering inhaled fluticasone as a cause for unexplained oedema in children.
Area of Science:
- Pediatric Endocrinology
- Pulmonology
- Clinical Pharmacology
Background:
- Peripheral oedema is a common clinical sign with numerous potential causes.
- Inhaled corticosteroids are widely used for managing pediatric asthma.
- Identifying the etiology of persistent peripheral oedema can be challenging.
Observation:
- A 14-year-old female presented with persistent, gross peripheral oedema for two years.
- Extensive investigations by multiple pediatric specialists failed to identify an underlying cause.
- The oedema resolved after discontinuation of inhaled fluticasone, prescribed for asthma management.
Findings:
- This report details the first known case of peripheral oedema associated with inhaled fluticasone use.
- Peripheral oedema is identified as a rare adverse effect of fluticasone, including formulations like Seretide and Flixotide.
- The patient's condition resolved upon cessation of the medication, suggesting a causal link.
Implications:
- Clinicians should consider inhaled fluticasone as a potential cause of unexplained peripheral oedema in pediatric patients.
- This finding expands the known side effect profile of inhaled fluticasone.
- Awareness of this rare adverse effect is crucial for accurate diagnosis and management of resistant peripheral oedema.
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