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Updated: May 20, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Proanthocyanidin-rich grape seed extract reduces leg swelling in healthy women during prolonged sitting
Atsushi Sano1, Shoichi Tokutake, Akihiko Seo
1Research and Development Division, Kikkoman Co., 399 Noda, Noda, Chiba, Japan. asano@mail.kikkoman.co.jp
Background:
Leg swelling is a modern-day affliction of sedentary working women. The aim of this study was to evaluate the effectiveness of the intake of grape seed extract (GSE) on leg swelling in healthy Japanese women while sitting.
Results:
Single intake trials and 14 day intake trials were held in a double-blind, placebo-controlled, crossover clinical study. A prolonged sedentary position was maintained for 6 h after GSE or placebo administration. Leg volume distension, increase in body extracellular fluid, and leg water were significantly suppressed in the GSE groups.
Conclusion:
The intake of GSE is a contributing factor in the inhibition of leg swelling in healthy women during prolonged sitting.
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