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Updated: May 20, 2026
08:26
Measuring the 50% Haemolytic Complement (CH50) Activity of Serum
Published on: March 29, 2010
Phenylethanoid glycosides from Monochasma savatieri and their anticomplement activity through the classical pathway
Min Li1, Meng-Fan Shi, Yan-Li Liu
1College of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Planta Medica
|July 4, 2012
Summary
Five new compounds, savasides A-E, were discovered in Monochasma savatieri. These phenylethanoid glycosides were tested for their anticomplement activity via the classical pathway.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Immunology
Background:
- Monochasma savatieri Franch. is a plant source of bioactive compounds.
- Phenylethanoid glycosides are a class of natural products with diverse biological activities.
- The complement system plays a crucial role in innate immunity and inflammation.
Purpose of the Study:
- To isolate and characterize new phenylethanoid glycosides from Monochasma savatieri.
- To evaluate the anticomplement activity of the isolated compounds.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using spectroscopic methods (NMR, MS).
- Anticomplement activity assay via the classical pathway.
Main Results:
- Five new phenylethanoid glycosides, savasides A-E (1-5), were identified.
- Six known phenylethanoid glycosides were also isolated.
- The anticomplement activity of all isolated compounds was assessed.
Conclusions:
- The study successfully identified novel phenylethanoid glycosides from Monochasma savatieri.
- The isolated compounds represent potential modulators of the classical complement pathway.
- Further investigation into the mechanism of action is warranted.
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