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Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...

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A Cell Culture Model for Producing High Titer Hepatitis E Virus Stocks
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Hepatitis delta: on soft paws across Germany.

C Reinheimer1, H W Doerr, A Berger

  • 1Institute of Medical Virology, Hospital of the Johann Wolfgang Goethe University, 60596, Frankfurt am Main, Germany. claudia.reinheimer@kgu.de

Infection
|July 4, 2012
PubMed
Summary

Hepatitis B virus (HBV) carriers in Germany show a 7.4% prevalence of hepatitis delta virus (HDV) coinfection. Vaccination against HBV is crucial for preventing HDV infection and its severe consequences like cirrhosis.

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Area of Science:

  • Hepatology
  • Virology
  • Epidemiology

Background:

  • Hepatitis B virus (HBV) chronically infects over 350 million people globally.
  • 15-20 million HBV carriers are coinfected with hepatitis delta virus (HDV).
  • HDV superinfection significantly increases the risk of cirrhosis.

Purpose of the Study:

  • To evaluate the seroprevalence of anti-HDV-IgG in HBV carriers in Germany.
  • To provide updated data on HDV prevalence, as existing data are scarce and outdated.
  • To assess trends in anti-HDV-IgG seropositivity over time.

Main Methods:

  • Retrospective analysis of serum samples from 2,844 patients positive for hepatitis B surface antigen (HBsAg).
  • Samples were collected between January 2000 and October 2011 at University Hospital Frankfurt am Main.
  • Anti-HDV-IgG was detected using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • Overall anti-HDV-IgG seroprevalence was 7.4% (95% CI: 6.4-8.4) in the Frankfurt cohort.
  • Seropositivity was higher in men (8.3%) compared to women (5.7%).
  • Seroprevalence peaked in 2003 (10.1%) and was lowest in 2004 (5.4%).

Conclusions:

  • Approximately 5-8% of HBV carriers in Germany show serologic evidence of HDV coinfection.
  • HBV vaccination is the primary strategy to prevent HDV infection.
  • Widespread promotion of HBV vaccination is essential to reduce HDV transmission and disease progression.