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Blood vessel normalization in the hamster oral cancer model for experimental cancer therapy studies
Ana J Molinari1, Romina F Aromando, Maria E Itoiz
1Department of Radiobiology, National Atomic Energy Commission, San Martin, Buenos Aires, Argentina.
Background:
Normalization of tumor blood vessels improves drug and oxygen delivery to cancer cells. The aim of this study was to develop a technique to normalize blood vessels in the hamster cheek pouch model of oral cancer.
Materials And Methods:
Tumor-bearing hamsters were treated with thalidomide and were compared with controls.
Results:
Twenty eight hours after treatment with thalidomide, the blood vessels of premalignant tissue observable in vivo became narrower and less tortuous than those of controls; Evans Blue Dye extravasation in tumor was significantly reduced (indicating a reduction in aberrant tumor vascular hyperpermeability that compromises blood flow), and tumor blood vessel morphology in histological sections, labeled for Factor VIII, revealed a significant reduction in compressive forces. These findings indicated blood vessel normalization with a window of 48 h.
Conclusion:
The technique developed herein has rendered the hamster oral cancer model amenable to research, with the potential benefit of vascular normalization in head and neck cancer therapy.
