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Updated: May 20, 2026

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Using Synthetic Biology to Engineer Living Cells That Interface with Programmable Materials

Published on: March 9, 2017

Metabolic engineering of bacteria.

Ravi R Kumar¹, Satish Prasad

¹Department of Biotechnology, Shree M. & N. Virani Science College, Rajkot, 360005 India.

Indian Journal of Microbiology

|July 4, 2012

Summary

Metabolic engineering enhances bioprocesses by genetically modifying microorganisms to increase target metabolite production. This approach optimizes yields for biotechnological applications and offers potential solutions for metabolic diseases and environmental issues.

Keywords:

Biosynthetic pathway Metabolic disease Metabolic network Recombinant DNA technology

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Area of Science:

Biotechnology and metabolic engineering

Background:

Bioprocess economics and viability depend critically on yield and productivity.
Metabolic engineering aims to increase target metabolite production through genetic manipulation.
Recombinant DNA technology provides tools for genetic modification of biosynthetic pathways.

Purpose of the Study:

To increase target metabolite production through genetic engineering.
To optimize existing bioprocesses for chemical production from renewable biomass.
To explore the potential of metabolic engineering for industrial applications, metabolic diseases, and environmental solutions.

Main Methods:

Genetic engineering of microorganisms (e.g., Escherichia coli, Actinomycetes) as biocatalysts.
Manipulation of biosynthetic pathways using recombinant DNA technology.
Optimization of fermentation parameters such as oxygenation, temperature, and pH.

Main Results:

Improved yields and productivity in bioprocesses.
Development of microbial biocatalysts for biotechnological production of chemicals.
Demonstrated scope for industrial applications of bacterial metabolic engineering.

Conclusions:

Metabolic engineering is a powerful tool for enhancing bioprocess yields.
This technology has significant potential in industrial biotechnology.
Metabolic engineering may offer future solutions for metabolic diseases and environmental challenges.