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Karyotypic findings in chronic myeloid leukemia cases undergoing treatment
Anupam Kaur1, Simran Preet Kaur, Amarjit Singh
1Centre for Genetic Disorders, Guru Nanak Dev University, Amritsar, Punjab, India.
Background:
Chronic myeloid leukemia (CML) is a clonal myeloproliferative expansion of primitive hematopoietic progenitor cells.
Materials And Methods:
In the present study, CML samples were collected from various hospitals in Amritsar, Jalandhar and Ludhiana.
Results:
Chromosomal alterations seen in peripheral blood lymphocytes of these treated and untreated cases of CML were satellite associations, double minutes, random loss, gain of C group chromosomes and presence of marker chromosome. No aberrations were observed in control samples. Karyotypic abnormalities have also been noted in the Ph-negative cells of some patients in disease remission.
Conclusion:
This is a novel phenomenon whose prognostic implications require thorough and systematic evaluation.
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