Related Experiment Video
Updated: May 20, 2026
07:16
Thermal Ablation for the Treatment of Abdominal Tumors
Published on: March 7, 2011
CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection
Rebecca Waitz1, Marcella Fassò, James P Allison
1Department of Immunology; Memorial Sloan-Kettering Cancer Center; Howard Hughes Medical Institute; New York, NY USA.
Oncoimmunology
|July 4, 2012
Abstract:
We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
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