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Immune reactivity in psoriatic munro-saboureau microabscesses, stratum corneum and blood vessels

Ana Maria Abreu-Velez1, Paul B Googe, Michael S Howard

  • 1Georgia Dermatopathology Associates, Atlanta, Georgia, USA.

North American Journal of Medical Sciences
|July 4, 2012
PubMed
Abstract

Insights

This study reveals significant correlations between Munro-Saboureau microabscesses in psoriasis and stratum corneum antibodies (SCAs), alongside other immunoreactants. These findings enhance understanding of psoriatic lesion development.

Area of Science:

  • Dermatology
  • Immunology
  • Pathology

Background:

  • Psoriatic lesions are characterized by neutrophil infiltration and Munro-Saboureau microabscesses.
  • Previous studies indicated stratum corneum antibodies (SCAs) within these microabscesses.

Purpose of the Study:

  • To investigate the correlation between SCAs and Munro-Saboureau microabscesses in psoriasis.
  • To identify other immunoreactants associated with these microabscesses.

Main Methods:

  • Examined 50 archival psoriasis biopsies with Munro-Saboureau microabscesses.
  • Utilized immunohistochemistry to detect antibody colocalization.
  • Compared findings with 50 healthy skin biopsies as controls.

Main Results:

  • Statistically significant positive markers in microabscesses compared to controls included CD1a, CD8, CD23, cyclooxygenase-2, albumin, fibrinogen, immunoglobulins (IgG, IgM, IgD), and complement factors (C3c, C3d).
  • Myeloperoxidase and carcinoembryonic antigen were also significantly elevated.
  • Autoreactivity to blood vessels involving immunoglobulins and complement was observed.

Conclusions:

  • Established significant correlations between Munro-Saboureau microabscesses and SCAs.
  • Identified numerous other immunoreactants co-localizing within these microabscesses.
  • These findings contribute to understanding the immunopathology of psoriasis.
Keywords:
AutoimmunityBlood vesselsMunro-Saboureau microabscesses carcinoembryonic antigenPsoriasisvon Willebrand factor

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