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Updated: May 20, 2026

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Standardized Technique of Aortic Valve Re-implantation for Valve-sparing Aortic Root Replacement

Published on: December 11, 2017

Strain transfer through the aortic valve.

Afshin Anssari-Benam¹, Himadri S Gupta, Hazel R C Screen

¹School of Engineering and Materials Science, Queen Mary, University of London, Mile End Road, E1 4NS London, UK.

Journal of Biomechanical Engineering

|July 5, 2012

Summary

This summary is machine-generated.

The aortic valve's fibrous network deforms non-uniformly, showing no direct strain transfer from tissue to network. This internal shearing may expose valve cells to damaging shear stresses.

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Area of Science:

Biomedical Engineering
Materials Science
Cardiovascular Research

Background:

The aortic valve (AV) extracellular matrix (ECM) has a complex structure enabling significant tissue deformation.
Collagen and elastin fibers form a fibrous network (FN) crucial for load-bearing in the AV matrix.
Understanding strain transfer within the AV ECM is vital for microstructural modeling.

Purpose of the Study:

To investigate the correlation between tissue-level strains and local fibrous network (FN) strains in the aortic valve (AV).
To characterize the mode of strain transfer (affine vs. nonaffine) through the AV tissue.
To analyze local FN deformation in response to applied tissue-level strains.

Main Methods:

Quantitative analysis of tissue-level strains applied to AV samples.
Measurement of macrostrains across the AV tissue surface.
Investigation of local FN strains within the AV ECM.

Main Results:

FN strain distribution across AV samples was inhomogeneous, nonuniform, and anisotropic.
No direct transfer of applied tissue-level deformation to the FN was observed.
Loading modes within the FN differed from applied tissue loads due to varying local strains.

Conclusions:

The study reveals a lack of direct strain transfer from the tissue to the fibrous network in the aortic valve.
Nonuniform local strains induce internal shearing within the AV's FN.
This internal shearing may expose aortic valve interstitial cells (AVICs) to potentially harmful shear strains and stresses.