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Oxygen Transport in the Blood

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Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...

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Updated: May 20, 2026

Live Cell Imaging during Mechanical Stretch

Live Cell Imaging during Mechanical Stretch

Published on: August 19, 2015

Stretching affects intracellular oxygen levels: three-dimensional multiphysics studies.

Efrat Leopold¹, Amit Gefen

¹Faculty of Engineering, Department of Biomedical Engineering, Tel Aviv University, Tel Aviv 69978, Israel.

Journal of Biomechanical Engineering

|July 5, 2012

Summary

This summary is machine-generated.

Multiphysics modeling reveals how cell deformation affects oxygen transport. Increased substrate stretch accelerates oxygen transport, while temperature drops have a milder effect, impacting cell respiration in bioengineering research.

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Area of Science:

Cellular bioengineering
Biophysics
Computational biology

Background:

Multiphysics modeling simulates complex biophysical interactions in cells.
Previous work developed cell-specific finite element modeling for cell deformation simulation.

Purpose of the Study:

Integrate finite element modeling with oxygen transport simulation.
Investigate effects of substrate stretch, oxygen concentration, and temperature on intracellular oxygen levels in myoblasts.

Main Methods:

Developed cell-specific finite element models for myoblasts.
Simulated oxygen transport within deformed cells under normoxic and hypoxic conditions.
Analyzed the influence of substrate stretch, oxygen concentration, and temperature.

Main Results:

Oxygen transport rate increased with substrate stretch (0-24%).
A 3°C temperature decrease had a less significant impact on oxygen transport than substrate stretch.
Cell geometry changes due to deformation can affect cellular respiration.

Conclusions:

Cellular mechanics experiments must consider the impact of externally applied deformations on intracellular oxygen levels.
Multiphysics modeling provides insights into cell viability and function under varying biophysical conditions.