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Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Drugs Affecting GI Tract Motility: Other Laxatives

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Related Experiment Video

Updated: May 20, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Obesity does not affect sodium picosulphate bowel preparation.

K C Fok1, I B Turner, W C Teoh

  • 1Department of Gastroenterology, Campbelltown Hospital, University of Western Sydney, Sydney, New South Wales, Australia. drianfok@gmail.com

Internal Medicine Journal
|July 5, 2012
PubMed
Summary

Obese and non-obese patients had similar bowel preparation quality using sodium picosulphate. This study highlights sodium picosulphate as an effective bowel preparation for obesity, ensuring colonoscopy quality.

Related Experiment Videos

Last Updated: May 20, 2026

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial (E-PACO): Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

Area of Science:

  • Gastroenterology
  • Endoscopy
  • Public Health

Background:

  • Previous research indicated obesity as a predictor of inadequate colonoscopy bowel preparation.
  • This study aimed to investigate bowel preparation quality in obese versus non-obese individuals.

Purpose of the Study:

  • To compare bowel preparation quality between obese and non-obese individuals using sodium picosulphate.
  • To assess efficacy using the Boston Bowel Preparation Scale (BBPS).

Main Methods:

  • Prospective study of 104 patients at a New South Wales hospital.
  • Bowel preparation administered using sodium picosulphate (Picoprep).
  • Body Mass Index (BMI) and epidemiological data collected; efficacy assessed via BBPS.

Main Results:

  • No statistical difference in bowel preparation quality between obese (36%) and non-obese (64%) patients (P > 0.99).
  • Good bowel preparation achieved in 89% of obese and 90% of non-obese patients.
  • Sodium picosulphate was well-tolerated, with nausea as the most common side effect.

Conclusions:

  • Sodium picosulphate provides comparable bowel preparation quality for obese and non-obese individuals.
  • The low-volume preparation is effective and well-tolerated in obese patients.
  • Ensuring procedural quality in obese patients is crucial given rising obesity rates.