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Published on: June 10, 2025
Disparities in heart failure and other cardiovascular diseases among women
Jean McSweeney1, Christina Pettey, Leanne L Lefler
1College of Nursing, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. mcsweeneyjeanc@uams.edu
Insights
Women face worse heart failure (HF) outcomes due to treatment disparities for conditions like myocardial infarction and hypertension. Factors like age, comorbidities, and socioeconomic status impact adherence to HF guidelines.
Area of Science:
- Cardiology
- Women's Health
- Health Disparities
Background:
- Cardiovascular diseases disproportionately affect women, particularly heart failure (HF).
- Existing research often overlooks gender-specific biological influences and treatment adherence challenges in women with HF.
Purpose of the Study:
- To review literature on cardiovascular disparities in women, with a focus on heart failure (HF).
- To examine the causes, biological factors, self-management, and treatment guideline adherence in women with HF.
Main Methods:
- Literature review of studies on cardiovascular disparities in women.
- Analysis of factors contributing to poorer HF outcomes in women compared to men.
Main Results:
- Women experience poorer HF outcomes due to disparities in managing conditions like myocardial infarction and hypertension.
- Nonadherence to HF medication is linked to advanced age, comorbidities, limited social support, and lower socioeconomic status.
- Limited inclusion of women in clinical trials hinders research applicability.
Conclusions:
- Addressing gender-specific factors is crucial for improving HF outcomes in women.
- Enhanced clinical trial diversity and gender-focused analyses are needed for cardiovascular diseases.
Abstract:
This article reviews literature pertinent to cardiovascular disparities in women, focusing primarily on heart failure (HF). It provides an in-depth look at causes, biological influences, self-management and lack of adherence to HF-treatment guidelines in women. Disparities in treatment of causative factors of HF, such as myocardial infarction and hypertension, contribute to women having poorer HF outcomes than men. This article discusses major contributing reasons for nonadherence to medication regimes for HF in women, including advanced age at time of diagnosis, likelihood of multiple comorbidities, lack of social support and low socioeconomic status. Limited inclusion of women in clinical trials and the scarcity of gender analyses for HF and other cardiovascular diseases continues to limit the applicability of research findings to women.
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