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Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...

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Related Experiment Video

Updated: May 20, 2026

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
04:01

A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice

Published on: June 14, 2024

Sepsis-induced cardiomyopathy.

Francisco J Romero-Bermejo1, Manuel Ruiz-Bailen, Julian Gil-Cebrian

  • 1Intensive Care Unit, Critical Care and Emergency Department, Puerto Real University Hospital, Cadiz, Spain. romerobermejo@gmail.com

Current Cardiology Reviews
|July 5, 2012
PubMed
Summary

Sepsis-induced myocardial dysfunction significantly predicts poor outcomes in patients, despite being reversible. This review covers its clinical presentation, pathophysiology, and current therapeutic strategies.

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A Preclinical Model of Sepsis-Induced Myopathy with Disuse in Mice
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Area of Science:

  • Cardiology
  • Critical Care Medicine
  • Pathophysiology

Background:

  • Sepsis-induced myocardial dysfunction is a critical factor in patient outcomes, with high mortality rates.
  • It involves biventricular dilation and reduced ejection fraction, often unresponsive to standard treatments.
  • Despite extensive research, its exact cause and effective treatments remain elusive.

Purpose of the Study:

  • To review the key aspects of sepsis-induced myocardial dysfunction.
  • To discuss its clinical presentation, pathophysiology, and etiopathogenesis.
  • To explore diagnostic tools and recent therapeutic strategies.

Main Methods:

  • Literature review of sepsis-induced myocardial dysfunction.
  • Analysis of clinical presentation and pathophysiology.
  • Evaluation of diagnostic and therapeutic approaches.

Main Results:

  • Sepsis-induced myocardial dysfunction is a significant predictor of mortality.
  • The condition affects both ventricles and shows limited response to fluid resuscitation and catecholamines.
  • Reversibility is typically observed within 7-10 days, but effective treatments are lacking.

Conclusions:

  • Understanding sepsis-induced myocardial dysfunction is crucial for improving patient outcomes.
  • Further research is needed to elucidate its etiopathogenesis and develop effective treatments.
  • This review consolidates current knowledge on diagnosis and therapy.