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Consistent sequential activity across diverse forms of UP states under ketamine anesthesia
1Canadian Centre for Behavioural Neuroscience, University of Lethbridge, 4401 University Drive, Lethbridge, AB, Canada, T1K 3M4. luczak@uleth.ca
The European Journal of Neuroscience
|July 5, 2012
Summary
During slow-wave sleep, neocortical UP states exhibit diverse global patterns but consistent neuronal firing. This research reveals stable, fine-structured activity within these brain states under anesthesia.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Neocortex exhibits complex, self-organized spontaneous activity during slow-wave sleep.
- Similar slow-wave oscillations, characterized by UP and DOWN states, occur under anesthesia.
Purpose of the Study:
- Investigate neuronal activity patterns during UP states in the neocortex.
- Characterize the diversity and conserved temporal dynamics of UP states.
Main Methods:
- Simultaneous multi-unit recordings from neocortical layer V in ketamine/xylazine-anesthetized rats.
- Analysis of field potentials, spiking activity, and cross-correlograms.
- Classification of UP states based on onset and propagation patterns.
Main Results:
- UP states showed diversity in onset, field potentials (10-14 Hz modulation), and propagation ('traveling waves').
- Despite global variability, conserved temporal firing relationships among neurons were observed.
- Putative interneurons fired early in UP states; pyramidal cells fired throughout.
Conclusions:
- Neocortical UP states under ketamine anesthesia possess stable, fine-structured neuronal firing patterns.
- This stability persists despite significant variability in global UP state characteristics.
- Identified conserved temporal relationships and cell-type-specific activity patterns during neocortical UP states.
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