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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension

Published on: June 6, 2025

Blood pressure in renal disease: how to accomplish the goal?

Nicolás R Robles, Roman Hernandez-Gallego

    Cardiovascular Therapeutics
    |July 5, 2012
    PubMed

    Insights

    The ACCOMPLISH trial found that benazepril plus amlodipine better protected kidneys and cardiovascular health in hypertensive patients than benazepril plus hydrochlorothiazide. This supports using calcium channel blockers with renin-angiotensin blockers for kidney and heart protection.

    Area of Science:

    • Nephrology
    • Cardiology
    • Pharmacology

    Background:

    • The ACCOMPLISH trial evaluated initial antihypertensive regimens for patients with systolic hypertension.
    • It compared benazepril plus amlodipine against benazepril plus hydrochlorothiazide.

    Discussion:

    • This review examines the ACCOMPLISH trial's renal findings regarding chronic kidney disease progression.
    • It assesses the data's validity and its relation to existing evidence on calcium antagonists in renal disease.

    Key Insights:

    • Initial therapy with benazepril plus amlodipine demonstrated superiority over benazepril plus hydrochlorothiazide.
    • This combination effectively reduced chronic kidney disease progression and cardiovascular events in renal patients.

    Outlook:

    • The findings support calcium channel blockers as a preferred second-line agent when added to renin-angiotensin axis blockers.
    • Further research may explore long-term renal and cardiovascular outcomes with this combination therapy.

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