Related Experiment Video
Updated: May 20, 2026
Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
The role of radiation therapy for uterine cervical cancer with distant metastasis
Masaharu Hata1, Motoko Omura, Etsuko Miyagi
1Department of Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan. mhata@syd.odn.ne.jp
Objective:
We carried out a review to determine the role of radiation therapy in uterine cervical cancer with distant metastasis.
Methods:
Forty-four patients with uterine cervical cancer with distant metastasis underwent radiation therapy; 29 of these also underwent chemotherapy. A total dose of 19.8-90.4 Gy (median 62.9 Gy) was delivered to the cervical tumors.
Results:
Thirty-three patients died during the follow-up period of 1-94 months (median 10 months) after irradiation. The overall survival rate at 3 years was 20%, and the estimated median survival time was 15 months. Ten patients developed primary tumor progression, and the primary tumor control rate at 3 years was 49%. A distant metastatic site and primary tumor size were significant prognostic factors for their survival. Total radiation dose was considered a significant and useful variable for primary tumor control. With the exception of transient hematologic reactions and hemorrhagic cystitis, there were no therapy-related toxicities of grade 3 or greater.
Conclusions:
Radiation therapy was safe and effective for local control in patients with uterine cervical cancer with distant metastasis. More aggressive treatment, including radiation therapy with a curative radiation dose, should be considered for patients with favorable prognostic factors for survival.
