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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

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Related Experiment Video

Updated: May 20, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Common hippocampal structural and functional changes in migraine.

Nasim Maleki1, Lino Becerra, Jennifer Brawn

  • 1Department of Anesthesia and Radiology, Center for Pain and the Brain, MCL, MGH and CHB, Children's Hospital Boston and Harvard Medical School, Boston, MA, USA.

Brain Structure & Function
|July 5, 2012
PubMed
Summary
This summary is machine-generated.

Migraine attacks, viewed as stressors, may alter the hippocampus. Lower frequency migraine patients showed larger hippocampal volume and greater deactivation, suggesting initial adaptation before dysfunction in high-frequency migraine.

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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Last Updated: May 20, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

Area of Science:

  • Neuroscience
  • Neurology
  • Medical Imaging

Background:

  • The hippocampus plays key roles in memory, navigation, and stress response.
  • Migraine attacks can be considered repeated stressors, potentially impacting hippocampal function.
  • Understanding hippocampal involvement is crucial for migraine pathophysiology.

Purpose of the Study:

  • To investigate morphometric and functional hippocampal differences in episodic migraine patients with varying attack frequencies.
  • To compare these differences with healthy controls.

Main Methods:

  • High-resolution magnetic resonance imaging (MRI) was used.
  • Hippocampal volume and functional activity (during noxious heat stimulation) were assessed.
  • Comparisons were made between low-frequency (LF) and high-frequency (HF) migraine groups, and healthy controls (HC).

Main Results:

  • Larger bilateral hippocampal volume was observed in the LF group compared to HF and HC groups.
  • Greater hippocampal deactivation in response to noxious stimulation was found in the LF group (LF > HF).
  • The HF group showed reduced functional connectivity between the hippocampus and pain-processing brain regions.

Conclusions:

  • Hippocampal volume and function alterations are implicated in migraine pathophysiology.
  • Larger hippocampal volume in LF migraineurs may represent adaptive plasticity.
  • Increased migraine frequency may lead to dysfunctional hippocampal changes and impaired connectivity.