Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

Exercise and Muscle Performance

Exercise and Muscle Performance

Exercise induces a range of adaptations in muscle tissue, depending on the type and duration of activity. Such physical training can be broadly categorized into two types: endurance exercises and resistance exercises.
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Are exercise booster sessions effective at preserving exercise-induced effects in people with multiple sclerosis? A randomised controlled trial: results from the MSBOOST trial.

Journal of science and medicine in sport·2026

Same author

Associations between fatigue impact and physical and neurobehavioural factors: An exploration in people with progressive multiple sclerosis.

Multiple sclerosis and related disorders·2024

Same author

Profiling cognitive-motor interference in a large sample of persons with progressive multiple sclerosis and impaired processing speed: results from the CogEx study.

Journal of neurology·2023

Same author

Hip kinematics and kinetics in patients with femoroacetabular impingement syndrome before and 1 year after hip arthroscopic surgery. Results from the HAFAI cohort.

Archives of orthopaedic and trauma surgery·2021

Same author

No association between femoral or acetabular angles and patient-reported outcomes in patients with femoroacetabular impingement syndrome-results from the HAFAI cohort.

Journal of hip preservation surgery·2020

Same author

Time matters: Early-phase multiple sclerosis is accompanied by considerable impairments across multiple domains.

Multiple sclerosis (Houndmills, Basingstoke, England)·2020

Search research articles

Related Experiment Video

Updated: May 20, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Multiple sclerosis and progressive resistance training: a systematic review.

T Kjølhede¹, K Vissing, U Dalgas

¹Section of Sport Science, Department of Public Health, Aarhus University, Dalgas Avenue 4, 8000 Aarhus C, Denmark.

Multiple Sclerosis (Houndmills, Basingstoke, England)

|July 5, 2012

Summary

Progressive resistance training (PRT) significantly improves muscle strength in individuals with multiple sclerosis (MS). While effects on function and well-being are less conclusive, PRT shows promise for MS rehabilitation.

More Related Videos

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Related Experiment Videos

Last Updated: May 20, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis

Published on: January 29, 2016

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Versatility of Protocols for Resistance Training and Assessment Using Static and Dynamic Ladders in Animal Models

Published on: December 17, 2021

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Dosage-Adjusted Resistance Training in Mice with a Reduced Risk of Muscle Damage

Published on: August 31, 2022

Area of Science:

Neurology
Rehabilitation Medicine
Exercise Science

Background:

Multiple sclerosis (MS) is a chronic neurological disease impacting mobility and quality of life.
Progressive resistance training (PRT) is increasingly recognized for its rehabilitative potential in MS.
Evidence on PRT's comprehensive effects in MS requires systematic evaluation.

Purpose of the Study:

To systematically review existing literature on the effects of PRT in individuals with MS.
To assess the quality of evidence for PRT's impact on strength, function, and other outcomes in MS.
To identify gaps in research regarding PRT mechanisms and protocols for MS.

Main Methods:

Comprehensive literature search across multiple databases (PubMed, Embase, Cochrane, etc.).
Inclusion of 16 studies, with quality assessment using the PEDro scale.
Analysis of PRT effects on muscle strength, functional capacity, balance, fatigue, quality of life, mood, and underlying biological mechanisms.

Main Results:

Strong evidence supports PRT's positive effect on muscle strength in persons with MS.
Evidence for improvements in functional capacity, balance, and self-reported measures is less robust but generally positive.
Limited and inconclusive findings exist regarding PRT's impact on muscle morphology, neural adaptations, and cytokines.

Conclusions:

PRT is an effective intervention for enhancing muscle strength in individuals with MS.
Variability in training protocols and MS characteristics contributes to heterogeneous outcomes in functional capacity and self-reported measures.
Further research is needed to explore the underlying mechanisms and optimize PRT protocols for MS rehabilitation.