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Updated: May 20, 2026

Isolation of Neonatal Extrahepatic Cholangiocytes
Published on: June 5, 2014
[The new paradigm of neonatal hemochromatosis: fetal alloimmune hepatitis]
Alejandro Costaguta1, Fernando Alvarez
1Unidad de Hígado y Trasplante Hepático, Sanatorio de Niños, Rosario, Argentina. alejandro.costaguta@gmail.com
Abstract:
The classical model of neonatal hemochromatosis was based on the analogy with hereditary hemochromatosis. Medical treatment consisted on the antioxidant-chelator cocktail. The new hypothesis of an alloimmune origin of the process by which the pregnant woman mounts an IgG-based destructive response against fetal hepatocytes offers a pathogenic explanation, allowing treatment to be focused on the immunological aspects, with excellent results, and opens the possibility of preventive treatment in future pregnancies. This new paradigm produces a deep impact in diagnosis, prognosis and treatment of the disease, that should be called "fetal alloimmune hepatitis".
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