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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

1,2,4-trisubstituted cyclopentanes as platforms for diversity

Yousheng Guan1, Caterina Bissantz, Donald E Bergstrom

  • 1Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University School of Pharmacy and Pharmaceutical Sciences, West Lafayette, IN, USA.

Archiv Der Pharmazie
|July 5, 2012
PubMed
Summary

Researchers developed efficient synthetic methods to create diverse amino-, azido-, and hydroxy-substituted cyclopentanes from cyclopent-3-en-1-ol. Stereochemical control during epoxidation allows for versatile intermediate generation for complex molecule synthesis.

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