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Effects of fish oil supplementation on cardiac function in chronic heart failure: a meta-analysis of randomised

Wei Xin1, Wei Wei, Xiaoying Li

  • 1First Department of Geriatric Cardiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. lixy301@163.com

Heart (British Cardiac Society)
|July 5, 2012
PubMed

Insights

Fish oil supplementation significantly improved cardiac function in patients with chronic heart failure (CHF), particularly enhancing left ventricular ejection fraction. These benefits were more pronounced in individuals with non-ischaemic heart failure.

Area of Science:

  • Cardiology
  • Nutritional Science

Background:

  • The therapeutic effects of fish oil on cardiac function in chronic heart failure (CHF) patients are debated.
  • Existing research presents conflicting findings regarding its impact on ventricular remodeling and functional capacity.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the effects of fish oil supplementation on cardiac function and related parameters in patients diagnosed with CHF.
  • To synthesize evidence from randomized controlled trials to clarify the role of fish oil in managing CHF.

Main Methods:

  • Systematic literature search of Medline, Embase, and the Cochrane Library.
  • Inclusion of 7 randomized controlled trials involving 825 participants with CHF.
  • Meta-analysis using fixed or random effect models to assess combined outcomes.

Main Results:

  • Fish oil supplementation significantly increased left ventricular ejection fraction (WMD = 2.25%) and decreased left ventricular end-systolic volume (WMD = 7.85 ml).
  • Improvements in cardiac function were more significant in patients with non-ischaemic heart failure.
  • Enhanced New York Heart Association functional classification and peak oxygen consumption were observed in the non-ischaemic subgroup.

Conclusions:

  • Fish oil may offer therapeutic benefits for CHF patients by improving cardiac function, ventricular remodeling, and functional capacity.
  • The positive effects of fish oil appear to be more pronounced in patients with non-ischaemic heart failure, suggesting a targeted therapeutic potential.
Abstract

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