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Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
Elevated ApoB serum levels strongly predict early cardiovascular events.
Bruna Gigante1, Karin Leander, Max Vikstrom
1Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, IMM, Nobelsväg 13, Karolinska Institutet, 17177 Stockholm, Sweden. bruna.gigante@ki.se
Heart (British Cardiac Society)
|July 5, 2012
Summary
Elevated apolipoprotein B (ApoB) serum levels predict an increased risk of early cardiovascular events in 60-year-olds. High ApoB levels were associated with a nearly two-year earlier onset of cardiovascular disease.
Area of Science:
- Cardiovascular Research
- Lipid Metabolism
- Epidemiology
Background:
- Apolipoprotein B (ApoB) is implicated in pro-thrombotic and pro-atherogenic processes.
- ApoB contributes to the progression of atherosclerotic lesions.
Purpose of the Study:
- To investigate if elevated ApoB serum levels predict the risk of premature cardiovascular events.
- Study conducted in a prospective Swedish cohort of 60-year-old men and women in Stockholm.
Main Methods:
- Prospective cohort study of 4232 individuals aged 60 in Stockholm (1997-1998).
- Cardiovascular disease incidence recorded via national registries.
- Cox and Laplace regression used to analyze risk and time to first cardiovascular event based on ApoB levels (≥0.9 g/l).
Main Results:
- High ApoB serum levels (≥0.9 g/l) were associated with an increased risk of cardiovascular diseases over 11 years.
- Adjusted hazard ratio for cardiovascular disease decreased from 2.49 at 4 years to 1.36 at 11 years.
- Individuals with high ApoB experienced cardiovascular events approximately 2 years earlier (p=0.001).
Conclusions:
- Increased ApoB serum levels are significant predictors of early cardiovascular events.
- The findings suggest ApoB's role may shift from pro-thrombotic to pro-atherogenic over time.
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