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Related Experiment Video

Updated: May 20, 2026

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets
10:14

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

Update on islet transplantation.

Michael McCall1, A M James Shapiro

  • 1Clinical Islet Transplant Program and Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.

Cold Spring Harbor Perspectives in Medicine
|July 5, 2012
PubMed
Summary
This summary is machine-generated.

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Clinical islet transplantation has advanced significantly for type 1 diabetes, offering hope for brittle control. Overcoming donor limitations and immunosuppression needs are key to making this a cure for all diabetes types.

Area of Science:

  • Endocrinology
  • Immunology
  • Regenerative Medicine

Background:

  • Clinical islet transplantation has seen substantial progress over 12 years, with over 750 international procedures for type 1 diabetes.
  • The transition from research to funded clinical care is occurring, particularly for patients with unstable glycemic control.
  • Significant challenges persist, including the need for multiple donors and potent, long-term immunosuppression.

Purpose of the Study:

  • To review the advancements and current status of clinical islet transplantation.
  • To identify the major challenges hindering wider application and potential curative status.
  • To highlight future directions for overcoming existing hurdles in islet cell replacement therapy.

Main Methods:

  • Review of international clinical islet transplantation data over the past 12 years.

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Last Updated: May 20, 2026

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10:14

Inguinal Subcutaneous White Adipose Tissue (ISWAT) Transplantation Model of Murine Islets

Published on: February 16, 2020

A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation
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A Method for Murine Islet Isolation and Subcapsular Kidney Transplantation

Published on: April 13, 2011

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  • Analysis of current clinical practice trends and acceptance.
  • Identification and discussion of key immunological and cellular source challenges.

    • Main Results:

    • Over 750 patients have undergone islet transplantation globally.
    • Islet transplantation is increasingly recognized for managing difficult-to-control diabetes.
    • Key obstacles include donor scarcity and the necessity for chronic immunosuppression.

    Conclusions:

    • Clinical islet transplantation is an evolving therapy for type 1 diabetes, moving towards clinical acceptance.
    • Achieving immunological tolerance and securing an unlimited cell source are critical for broader application.
    • Future research should focus on overcoming these barriers to potentially cure type 1 and type 2 diabetes.