Related Experiment Video
Updated: May 20, 2026
08:41
Mouse Round Spermatid Injection
Published on: January 26, 2024
Eruption delay in a 47 XXY male: a case report
G D'Alessandro1, L Armuzzi, G Cocchi
1Department of Dental Science, Dental School, Alma Mater Studiorum, University of Bologna, Bologna, Italy. dr.dalessandro@gmail.com
European Journal of Paediatric Dentistry
|July 6, 2012
Summary
Klinefelter syndrome (47,XXY) is the most common sex chromosome disorder in males. This case highlights a potential link between Klinefelter syndrome and delayed primary tooth eruption in infants.
Area of Science:
- Genetics
- Pediatrics
- Endocrinology
Background:
- 47,XXY syndrome, also known as Klinefelter syndrome, is the most frequent sex chromosome abnormality in males.
- It is often underdiagnosed and typically identified after puberty, but prenatal diagnosis is possible via chorionic villus sampling.
Observation:
- A 16-month-old Italian male with 47,XXY syndrome presented with delayed primary tooth eruption (8-10 months).
- Auxological development (weight and height) was normal, around the 50th percentile, during the first 15 months of life.
Findings:
- The observed delay in primary teeth eruption in this infant with Klinefelter syndrome suggests a potential association.
- Sexual chromosomes are implicated in influencing dental development, warranting further investigation.
Implications:
- This case suggests a possible correlation between Klinefelter syndrome and delayed dental development, even with normal overall growth.
- Early identification of such dental anomalies may aid in the earlier diagnosis of Klinefelter syndrome.
- Further research is needed to confirm the role of sex chromosomes in dental development delays associated with 47,XXY syndrome.
Related Concept Videos
01:43Sex-linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
01:43Sex Linked Disorders
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
02:19The Y Chromosome Determines Maleness
The Y chromosome is a sex chromosome found in several vertebrates and mammals, including humans. In addition to 22 pairs of autosomes, the human males have one X chromosome and one Y chromosome. In these organisms, the presence or absence of the Y chromosome determines the development of male traits.
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
01:20Disorders of the Male Reproductive System
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
02:32X and Y Chromosomes
Among mammals, the gender of an organism is determined by the sex chromosomes. Humans have two sex chromosomes, X and Y. Every human diploid cell has 22 pairs of autosomes and one pair of sex chromosomes. A human female has two X chromosomes, while a male has one X chromosome and one Y chromosome.
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
The germline cells such as egg and sperm cells carry only half the number of chromosomes, i.e., 22 autosomes and one sex chromosome. All eggs have an X chromosome, while sperm cells can carry an X or...
01:19X-linked Traits
In most mammalian species, females have two X sex chromosomes and males have an X and Y. As a result, mutations on the X chromosome in females may be masked by the presence of a normal allele on the second X. In contrast, a mutation on the X chromosome in males more often causes observable biological defects, as there is no normal X to compensate. Trait variations arising from mutations on the X chromosome are called “X-linked”.