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Updated: May 20, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
Malignant peripheral nerve sheath tumor arising from the left ventricle
Won-Chul Cho1, Sung-Ho Jung, Seung Hyun Lee
1Department of Thoracic and Cardiovascular Surgery, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Seoul, Korea.
This case report details the successful complete excision of a rare malignant peripheral nerve sheath tumor originating from the left ventricle. This highlights the possibility of surgical intervention for such uncommon cardiac tumors.
Area of Science:
- Cardiovascular Surgery
- Surgical Oncology
- Cardiac Pathology
Background:
- Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms.
- MPNSTs in the mediastinum, particularly involving the pericardium and heart, are exceptionally uncommon.
- Left ventricular tumors pose unique surgical challenges due to their location and potential for cardiac dysfunction.
Observation:
- A 32-year-old female presented with a malignant peripheral nerve sheath tumor.
- The tumor was identified as originating from the left ventricle.
- The patient underwent surgical intervention for complete tumor excision.
Findings:
- Complete excision of the malignant left ventricular peripheral nerve sheath tumor was achieved.
- The surgical outcome for this rare cardiac malignancy was successful.
- This case demonstrates the feasibility of radical resection for left ventricular MPNSTs.
Implications:
- Successful complete excision of a left ventricular malignant peripheral nerve sheath tumor is possible.
- This case expands the understanding of rare cardiac tumors and their surgical management.
- Further research into the optimal treatment strategies for cardiac MPNSTs is warranted.
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07:10Orthotopic Xenografting of Human Luciferase-Tagged Malignant Peripheral Nerve Sheath Tumor Cells for in vivo Testing of Candidate Therapeutic Agents
Published on: March 7, 2011
09:33Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
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