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Related Experiment Video

Updated: May 20, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

Published on: September 6, 2017

New updating into hemoglobinopathies.

S Fucharoen¹, P Winichagoon¹

¹Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakornpathom, Thailand.

International Journal of Laboratory Hematology

|July 6, 2012

Summary

This summary is machine-generated.

Thalassemia and abnormal hemoglobin disorders are common genetic conditions, particularly in developing nations. Advances in diagnosis, treatment, and prevention offer improved patient quality of life and potential cures.

Keywords:

Thalassemia hemoglobinopathy

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Last Updated: May 20, 2026

Detection of Residual Donor Erythroid Progenitor Cells after Hematopoietic Stem Cell Transplantation for Patients with Hemoglobinopathies

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Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

Genetics
Hematology
Public Health

Background:

Thalassemia and abnormal hemoglobin disorders represent significant global health challenges, especially in developing countries.
These genetic conditions are the most prevalent worldwide, necessitating effective management and control strategies.

Purpose of the Study:

To review recent advancements in the laboratory diagnosis, treatment, and control of thalassemia.
To highlight the importance of understanding genotype-phenotype interactions for therapeutic interventions.
To discuss current and future strategies for improving patient quality of life and achieving worldwide prevention.

Main Methods:

Literature review of recent progress in thalassemia diagnosis and treatment.
Analysis of genotype-phenotype correlations in alpha- and beta-thalassemia.
Evaluation of current therapeutic approaches and future prospects.

Main Results:

Significant progress has been made in laboratory diagnosis, treatment, and control of thalassemia.
Clinical severity variations are linked to genotype-phenotype interactions, crucial for targeted therapies.
Improved quality of life for patients is achievable through regular blood transfusions and novel iron chelators.

Conclusions:

Stem cell transplantation and gene therapy offer potential cures for thalassemia.
Characterizing genotype-phenotype interactions is vital for effective therapeutic interventions.
Multinational collaboration is expected to drive worldwide prevention of thalassemia.