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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Veins of Head and Neck01:19

Veins of Head and Neck

The blood drainage from the head and neck is primarily managed by three pairs of veins: the external jugular, internal jugular, and vertebral veins. The external jugular veins drain superficial scalp and face structures, passing over the sternocleidomastoid muscles to empty into the subclavian veins.
On the other hand, the vertebral veins, unlike their arterial counterparts, are not primarily responsible for brain drainage. Instead, they drain the cervical vertebrae, spinal cord, and some small...
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct regions...
Arteries of the Head and Neck01:26

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
External Anatomy of the Kidney01:21

External Anatomy of the Kidney

The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Anastomoses01:19

Anastomoses

In human anatomy, anastomosis refers to a connection or opening between two things, particularly between blood vessels or other tubular structures. The term is derived from the Greek term 'anastomosis,' which means 'outlet' or 'opening.' This natural network of connections plays a critical role in the survival and functionality of the human body.
Anastomoses can be formed at arterial, venous, and lymphatic vessels.
Arterial Anastomosis: These occur between arteries. They are most common in...

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Related Experiment Video

Updated: May 20, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

Angioadnexocentric nevus.

Ken Hashimoto1, Masahiro Amano, Mitsuru Setoyama

  • 1Department of Dermatology, Wayne State University School of Medicine, Detroit, Michigan, USA.

The Journal of Dermatology
|July 6, 2012
PubMed
Summary

Eccrine-centered nevus involves melanocytic nevus cells infiltrating eccrine glands and blood vessels. This study suggests a benign migratory behavior of nevus cells in fetal skin.

Area of Science:

  • Dermatopathology
  • Developmental Biology

Background:

  • Eccrine-centered nevus is a known association between melanocytic nevus and eccrine glands.
  • Non-giant congenital nevi can exhibit angiocentric and adnexocentric growth patterns of nevus cells.

Observation:

  • In the studied specimen, nevus cell infiltration was prominent around blood vessels and eccrine ducts, forming a linear distribution.
  • Initial examination suggested vascular pathologies like lymphocytic perivasculitis and erythema annulare centrifugum.
  • Immunohistochemistry (S-100) revealed nevus cell infiltration into vascular and ductal walls, while T cell (CD3, 4, 8) and B cell (CD20, 79a) markers were negative.

Findings:

  • S-100 immunostaining confirmed nevus cell penetration into vascular and ductal walls.
  • Negative Ki-67 staining in all cells indicated a benign nature of the lesion.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Characterization of Vascular Morphology of Neovascular Age-Related Macular Degeneration by Indocyanine Green Angiography
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Published on: August 11, 2023

  • The observed pattern supports a theory of random nevus cell migration in fetal skin, with cells propagating upon encountering barriers like blood vessels and eccrine ducts.

    • Implications:

    • The findings contribute to understanding the pathogenesis of eccrine-centered nevi.
    • This migratory behavior, particularly around vascular and ductal structures, may explain their prevalence in these locations.
    • The study highlights the importance of immunohistochemistry in differentiating benign nevus patterns from other pathologies.