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Fasting apolipoprotein B48 is associated with asymptomatic peripheral arterial disease in type 2 diabetic subjects: a

Emanuela Lapice1, Paola Cipriano, Lidia Patti

  • 1Department of Clinical and Experimental Medicine, University of Naples Federico II, Via S Pansini 5, 80131 Napoli, Italy. emanuela1978@hotmail.it

Atherosclerosis
|July 6, 2012
PubMed
Abstract

Insights

Fasting apolipoprotein B48 (ApoB48) levels are linked to peripheral artery disease (PAD) in type 2 diabetes patients. Higher ApoB48 indicates increased risk for PAD, independent of other factors.

Area of Science:

  • Cardiovascular Research
  • Diabetes Mellitus Research
  • Lipoprotein Metabolism

Background:

  • Intestinally derived triglyceride-rich lipoproteins (TRLs) and their remnants, identified by apolipoprotein B48 (ApoB48), are implicated in atherogenesis.
  • Peripheral artery disease (PAD) is a common complication of type 2 diabetes mellitus (T2DM).

Purpose of the Study:

  • To investigate the association between fasting ApoB48 levels and asymptomatic PAD in patients with T2DM.
  • To determine if this association is independent of traditional risk factors and plasma lipids.

Main Methods:

  • A cohort of 87 type 2 diabetes patients was studied, divided into 34 with asymptomatic PAD (Ankle/Brachial Index < 0.9) and 53 without PAD.
  • Participants were matched for age, gender, and BMI. Fasting plasma ApoB48 levels were quantified using ELISA.

Main Results:

  • Patients with PAD exhibited significantly higher fasting ApoB48 levels compared to those without PAD (1.529 ± 1.253 vs 1.095 ± 0.667 μg/ml, p=0.04).
  • This association remained significant after adjusting for confounders including diabetes duration, smoking, HbA1c, systolic blood pressure, and fasting plasma lipids.

Conclusions:

  • Fasting ApoB48 is an independent risk marker for asymptomatic peripheral artery disease in individuals with type 2 diabetes.
  • Elevated ApoB48 may signify increased atherogenic remnant lipoprotein levels contributing to PAD development in this population.

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