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Related Experiment Video

Updated: May 20, 2026

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
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Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

Albumin coated microbubble optimization: custom fabrication and comprehensive characterization.

Helen Mulvana1, Richard J Browning, Meng-Xing Tang

  • 1Department of Imaging Sciences, Imperial College London, United Kingdom.

Ultrasound in Medicine & Biology
|July 6, 2012
PubMed
Summary

Researchers found that altering albumin concentration during microbubble fabrication significantly impacts their properties. Lower albumin concentrations (2%) yielded microbubbles with enhanced acoustic scattering and more vigorous oscillations, improving their potential for medical imaging and drug delivery applications.

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Area of Science:

  • Biomedical Engineering
  • Acoustic Imaging
  • Materials Science

Background:

  • Gas microbubbles are crucial for enhancing contrast in medical diagnostic imaging.
  • Microbubble-enhanced quantitative imaging and drug delivery are rapidly advancing fields.
  • Optimizing microbubble properties is essential for improving their utility in these applications.

Purpose of the Study:

  • To investigate the feasibility of manipulating albumin-shelled microbubble properties.
  • To explore the effect of varying albumin concentration during fabrication on microbubble characteristics.
  • To assess the potential for tailoring microbubbles for specific applications.

Main Methods:

  • Fabrication of microbubbles using albumin suspensions of varying concentrations (2%, 5%, and 10%).

Related Experiment Videos

Last Updated: May 20, 2026

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers
10:40

Fabricating and Labeling Microbubbles with Fluorescent and Radioactive Tracers

Published on: January 24, 2025

  • Comprehensive physical and acoustic characterization of the fabricated microbubbles.
  • High-speed imaging to analyze radial oscillations.

    • Main Results:

    • Microbubbles fabricated from 2% albumin suspensions exhibited a higher scattering to attenuation ratio (STAR) (4.4%) compared to 10% albumin preparations (2.2%).
    • Nonlinear STAR was approximately doubled in 2% albumin microbubbles (1.5%) versus 10% preparations (0.7%).
    • 2% albumin microbubbles showed significantly greater (up to 40%) and more violent radial oscillations during high-speed imaging.

    Conclusions:

    • Microbubble characteristics can be effectively manipulated by simply altering albumin availability during fabrication.
    • Lower albumin concentrations lead to enhanced acoustic properties and dynamic behavior.
    • This simple manipulation offers opportunities to enhance microbubble utility for specific applications in medical imaging and drug delivery.