Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Biological Causes of Schizophrenia

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...

Psychological and Sociocultural Causes of Schizophrenia

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...

Negative and Cognitive Symptoms of Schizophrenia

Negative and Cognitive Symptoms of Schizophrenia

Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...

Schizophrenia

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes loosely...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The future of data analysis is now: Integrating generative AI in neuroimaging methods development.

Imaging neuroscience (Cambridge, Mass.)·2025

Same author

DTI microstructural abnormalities in adolescent siblings of patients with childhood-onset schizophrenia.

Psychiatry research. Neuroimaging·2016

Same author

Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia.

Schizophrenia research·2014

Same author

Divergent CSF τ alterations in two common tauopathies: Alzheimer's disease and progressive supranuclear palsy.

Journal of neurology, neurosurgery, and psychiatry·2014

Same author

Impaired automatization of a cognitive skill in first-degree relatives of patients with schizophrenia.

Psychiatry research·2013

Same author

Evidence for corticostriatal dysfunction during cognitive skill learning in adolescent siblings of patients with childhood-onset schizophrenia.

Schizophrenia bulletin·2013

Search research articles

Related Experiment Video

Updated: May 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Deficits in probabilistic classification learning and liability for schizophrenia.

Dana Wagshal¹, Barbara Jean Knowlton, Jessica Rachel Cohen

¹University of California Los Angeles, CA 90095, United States. dwagshal@ucla.edu

Psychiatry Research

|July 6, 2012

Summary

This summary is machine-generated.

Healthy siblings of patients with childhood-onset schizophrenia (COS) exhibit impaired cognitive skill learning. This deficit in probabilistic classification learning may indicate a genetic liability for schizophrenia.

More Related Videos

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

Related Experiment Videos

Last Updated: May 20, 2026

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

Operant Procedures for Assessing Behavioral Flexibility in Rats

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Multimodal Protocol for Assessing Metacognition and Self-Regulation in Adults with Learning Difficulties

Published on: September 27, 2020

Area of Science:

Neuroscience
Psychiatry
Genetics

Background:

Schizophrenia is associated with deficits in skill learning.
Cognitive skill learning impairments may indicate a genetic predisposition to schizophrenia.

Purpose of the Study:

To investigate cognitive skill learning in adolescent siblings of patients with childhood onset schizophrenia (COS).
To determine if impaired skill learning is present in unaffected siblings, suggesting genetic liability for schizophrenia.

Main Methods:

Utilized a probabilistic classification task to assess cognitive skill learning.
Compared learning performance between adolescent siblings of COS patients and age-matched controls.

Main Results:

Controls demonstrated significant learning within the first 50 trials, while COS siblings did not.
Siblings of COS probands achieved lower asymptotic performance after extensive training compared to controls.

Conclusions:

Unaffected siblings of COS patients exhibit deficits in probabilistic classification learning, mirroring those in patients.
This behavioral impairment suggests a potential genetic liability for schizophrenia in healthy siblings.