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Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

Effects of cancer on ovarian response in controlled ovarian stimulation for fertility preservation

Benny Almog¹, Foad Azem, David Gordon

¹Sarah Racine IVF Unit, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. bennyalmo@gmail.com

Fertility and Sterility

|July 6, 2012

Abstract

Objective:

To evaluate the effects of cancer on ovarian response in controlled ovarian hyperstimulation (COH).

Design:

Retrospective analysis study.

Setting:

University-based tertiary medical center.

Patient(S):

81 cancer patients undergoing controlled ovarian stimulation cycles for fertility preservation, and age- and date-matched controls undergoing COH for in vitro fertilization (IVF) for male factor infertility.

Intervention(S):

Controlled ovarian hyperstimulation and oocytes retrieval.

Main Outcome Measure(S):

Maximal estradiol levels at day of human chorionic gonadotropin administration, duration of stimulation, total amount of gonadotropins administered, number of dominant follicles, number of oocytes retrieved, and rate of metaphase 2 oocytes.

Result(S):

The overall number of dominant follicles and the number of oocytes aspirated of the study group and control were comparable (8.8 ± 5.3 vs. 9.7 ± 4.9, and 11.93 ± 8.3 vs. 12.3 ± 7.9, respectively). The total dose of gonadotropins used and number of stimulation days of the study group (2,250 IU [1,800-3,000 IU] and 9.5 [8-11]) were also similar to the controls (2,100 IU [1,700-2,900] and 10 [9-13]). Comparison between four subgroups of cancer-breast cancer, soft tissue sarcoma, hematologic malignancies, and gastrointestinal tract cancers-showed no difference in their ovarian response indexes. Regression analysis to assess the effect of cancer on ovarian response showed no effect on the main outcome measured.

Conclusion(S):

Cancer does not influence ovarian response in COH for fertility preservation.

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