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The role of interleukin-21 in HIV infection

Suresh Pallikkuth1, Anita Parmigiani, Savita Pahwa

  • 1Department of Microbiology & Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, United States.

Cytokine & Growth Factor Reviews
|July 6, 2012
PubMed

Interleukin (IL)-21 is one of a group of cytokines including IL-2, IL-4, IL-7, IL-9 and IL-15 whose receptor complexes share the common γ chain (γ(c)). Secretion of IL-21 is restricted mainly to T follicular helper (TFH) CD4 T cell subset with contributions from Th17, natural killer (NK) T cells, but the effects of IL-21 are pleiotropic, owing to the broad cellular distribution of the IL-21 receptor. The role of IL-21 in sustaining and regulating T cell, B cell and NK cell responses during chronic viral infections has recently come into focus. This chapter reviews current knowledge about the biology of IL-21 in the context of HIV infection.

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