[Pathology of glandular expansion in gastric mucosa from 674 cases biopsied]

Glandular expansion in the gastric mucosa from 674 cases biopsied was studied pathologically. Both simple glandular expansion and dysplastic glandular expansion were proposed. The latter, according to the degree of epithelial dysplasia, mucus content, accompanying glandular atrophy and/or intestinal metaplasia, could be divided into cystic glandular dysplasia and adenomatous dysplasia. Follow-up of repeated gastric mucosa biopsy showed that the simple glandular expansion is benign whereas dysplastic glandular expansion is precarcinomatous change with a malignant change rate of 9.9%. The authors consider that the malignant changes may follow the course: glandular expansion of gastric mucosa--enhancement of mucus secretion in gland lumina--epithelial hyperplasia--reduction of mucus secretion--formation of cystic glandular or adenomatous dysplasia--malignant change.