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Updated: May 20, 2026

Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

[Blood--a special resource]

Christof Geisen1, Michael Schmidt, Dieter Klarmann

  • 1Institut für Transfusionsmedizin und Immunhämatologie, DRKBlutspendedienstes Baden-Württemberg - Hessen in Frankfurt, Universität Frankfurt am Main, Germany. c.geisen@blutspende.de

Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
|July 6, 2012
PubMed

Haemotherapy is an integral part of modern high-tech medicine. Without supportive care including red blood cell (RBC), platelet concentrate (PC) and fresh frozen plasma (FFP) transfusion, invasive therapies such as high-dose chemotherapy regimens for haematological and solid malignancies, haematopoietic stem cell (HSC) and solid organ transplantation as well as major surgery and modern trauma management would not be possible. In this article we describe the current state of haemotherapy, the risk of adverse effects and risk minimization measures, specifically focussing on haemolytic transfusion reactions (HTR), transfusion-related lung injury (TRALI) and transfusion-transmitted infections (TTI). Aided by the introduction of NAT technology for blood component screening, the residual risk of transfusion transmitted infections was reduced to 1:10.8 million for HCV, to 1:4.3 million for HIV-1, and to 1:360,000 for HBV for blood products of the German Red Cross Blood Service.

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