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Related Concept Videos

Fusion of Secretory Vesicles with the Plasma Membrane01:26

Fusion of Secretory Vesicles with the Plasma Membrane

Proteins and neurotransmitters in secretory vesicles can be released from a cell upon vesicle docking, priming, and fusion with the plasma membrane. Vesicles are docked and primed in preparation for the quick exocytosis of their contents in response to a stimulus. The fusion process is mainly carried out by a SNAP Receptor or SNARE complex, consisting of synaptobrevin, syntaxin-1, and SNAP-25.
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Related Experiment Video

Updated: May 20, 2026

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons
07:30

Measuring Synaptic Vesicle Endocytosis in Cultured Hippocampal Neurons

Published on: September 4, 2017

Synaptic vesicle endocytosis.

Yasunori Saheki1, Pietro De Camilli

  • 1Department of Cell Biology, Howard Hughes Medical Institute and Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale University School of Medicine, New Haven, Connecticut 06510, USA.

Cold Spring Harbor Perspectives in Biology
|July 6, 2012
PubMed
Summary
This summary is machine-generated.

Neurons efficiently recycle synaptic vesicle membranes for sustained transmission. This process, synaptic vesicle endocytosis, utilizes general and neuron-specific mechanisms for membrane reuse.

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Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Neurons maintain high synaptic transmission rates without depleting synaptic vesicles.
  • This relies on efficient local endocytic recycling of synaptic vesicle membranes.
  • Membranes can be reused for thousands of exo-endocytic cycles.

Purpose of the Study:

  • To summarize current knowledge on synaptic vesicle endocytosis.
  • To emphasize the underlying molecular mechanisms.
  • To focus on clathrin-mediated endocytosis as the primary pathway.

Main Methods:

  • Review of morphological, physiological, molecular, and genetic studies.
  • Analysis of membrane traffic reactions governing recycling and regulation.
  • Focus on clathrin-mediated endocytosis.

Main Results:

  • Synaptic vesicle endocytosis employs fundamental endocytic mechanisms.
  • Neuron-specific adaptations of these mechanisms are involved.
  • Clathrin-mediated endocytosis is the predominant pathway for protein internalization.

Conclusions:

  • Synaptic vesicle endocytosis is crucial for sustained neuronal function.
  • Understanding these processes advances both synaptic transmission and general endocytosis research.