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Decrease in salivary lactoferrin output in chronically intoxicated alcohol-dependent patients.

Napoleon Waszkiewicz¹, Beata Zalewska-Szajda, Anna Zalewska

¹Department of Psychiatry, Medical University of Bialystok, Poland. napoleonwas@yahoo.com

Folia Histochemica Et Cytobiologica

|July 6, 2012

Summary

Chronic alcohol intoxication significantly reduces salivary flow and lactoferrin output, impacting oral health. This decrease in salivary lactoferrin may compromise the mouth's defense against pathogens and contribute to poorer periodontal health.

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A Method for the Measurement of Salivary Gland Function in Mice

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Published on: January 25, 2018

Area of Science:

Oral biology and immunology
Toxicology and public health

Background:

Salivary lactoferrin is a key glycoprotein for oral pathogen defense and microbial balance.
Elevated salivary lactoferrin can indicate salivary gland damage, gingivitis, or mucosal inflammation.
Chronic alcohol consumption's impact on salivary lactoferrin remains under-investigated.

Purpose of the Study:

To investigate the effect of chronic alcohol intoxication on salivary lactoferrin concentration and output.
To assess the relationship between alcohol consumption and oral health indicators like salivary flow and periodontal status.

Main Methods:

Study included 30 male volunteers: 10 with chronic alcohol intoxication (Group A) and 20 controls (Group C).
Resting whole saliva was collected 24-48 hours post-intoxication for lactoferrin analysis via ELISA.
Salivary flow rate, DMFT index, gingival index (GI), and papilla bleeding index (PBI) were assessed.

Main Results:

Significantly decreased salivary flow (SF) was observed in alcohol-dependent patients (Group A) compared to controls (Group C).
While salivary lactoferrin concentration showed no significant difference, lactoferrin output was significantly decreased in Group A.
A significant negative correlation was found between daily alcohol intake and lactoferrin output; Group A exhibited increased GI and PBI.

Conclusions:

Chronic alcohol intoxication leads to reduced salivary flow and diminished salivary lactoferrin output.
Decreased lactoferrin output may result from impaired biosynthesis, increased catabolism, or compromised neutrophil function due to ethanol.
Reduced salivary protection and flow in alcohol-dependent individuals may contribute to poorer periodontal health.