Isolation and some properties of bovine brain 100 kDa heat shock protein

H Itoh1, R Kobayashi, Y Tashima

  • 1Department of Biochemistry, Akita University School of Medicine, Japan.

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Molecular Chaperones and Protein Folding

The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
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