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Updated: May 20, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Renal function abnormalities after marathon run and 16-kilometre long-distance run
Miroslav Mydlík1, Katarína Derzsiová, Branislav Bohus
1IVth Internal Clinic, University Hospital of L. Pasteur and Medical School of P. J. Safárik University, Kosice, Slovak Republic.
Przeglad Lekarski
|July 7, 2012
Summary
Running a marathon or long-distance race temporarily impairs kidney function due to dehydration and muscle damage. These renal function abnormalities resolve within days after the run.
Area of Science:
- Exercise Physiology
- Nephrology
- Sports Medicine
Background:
- Endurance running events like marathons and long-distance races place significant physiological stress on the body.
- Understanding the impact of such events on renal function is crucial for athlete health and performance.
- Previous research has indicated potential kidney strain in athletes, but comprehensive analysis is needed.
Purpose of the Study:
- To investigate the effects of marathon and 16-km runs on various renal function parameters in athletes.
- To identify the specific biomarkers and physiological changes indicative of renal stress post-exercise.
- To determine the recovery timeline for renal function after strenuous running events.
Main Methods:
- Analysis of renal function markers in 29 marathon runners and 20 16-km runners before and after their respective events.
- Measurement of body weight, blood pressure, proteinuria, albuminuria, erythrocyturia, serum creatine kinase (CK) and its isoenzyme MB, serum myoglobin, urea, creatinine, phosphorus, and osmolality.
- Calculation of glomerular filtration rate (GFR) and fractional excretions (FE) of sodium, calcium, phosphorus, osmolality, and water.
Main Results:
- Significant increases in proteinuria, albuminuria, serum CK, myoglobin, urea, creatinine, phosphorus, and osmolality were observed post-run.
- Significant decreases in calculated GFR and fractional excretions of electrolytes and water were noted.
- Transient non-glomerular erythrocyturia and evidence of rhabdomyolysis were present in some runners.
- Renal function parameters returned to baseline within 2-6 days post-exercise.
Conclusions:
- Marathon and long-distance running induce temporary renal function abnormalities, primarily linked to dehydration, rhabdomyolysis, and protein catabolism.
- These exercise-induced renal changes are reversible, with full recovery typically occurring within a week.
- Athletes should be aware of these physiological responses and ensure adequate hydration and recovery.
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