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Updated: May 20, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
[Hepatitis B virus core antigen as a carrier for virus-like partical vaccine: a review]
Xing-Yu Yang1, Hong Bo, Yue-Long Shu
1World Health Orgnization Global Influenza Collaboration, Centre for Reference and Reaserch, State Key Laboratory for Molecular Virology and Genetic Enginering, Chinese Center for Disease Control and Prevention, National Institute for Viral Disease Control and Prevention, Beijing 102206, China. yangxingyu@cnic.org.cn
Abstract:
Hepatitis B virus core antigen (HBcAg) is a major viral nucleocapsid protein of HBV. It is a 21-22kD protein consisting of 183-185 amino acids. Because of its easy purification, strong immunogenicity, high expression level, and self-assembles into the virus-like particles (VLP), HBcAg could be an efficient and safe VLP carrier for developing vaccines for various pathogens. Up to now, HBcAg VLP carrier has been an important system to develop novel vaccines and many antigen epitope genes from viruses, bacteria and parasites were expressed successfully using the system.
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