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RECRUIT-TandAbs: harnessing the immune system to kill cancer cells

Fionnuala McAleese1, Markus Eser

  • 1Affimed Therapeutics AG, Technologiepark, Im Neuenheimer Feld 582, D-69120 Heidelberg, Germany. f.mcaleese@affimed.com

Future Oncology (London, England)
|July 7, 2012
PubMed

Insights

RECRUIT-Tandem diabodies (TandAbs) are novel bispecific molecules that target cancer cells and immune effector cells. This technology offers specific cancer cell killing with reduced side effects and improved pharmacokinetics.

Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Tandem diabodies (TandAbs) are tetravalent bispecific molecules engineered from antibody variable domains.
  • They possess dual binding sites for distinct antigens, enabling simultaneous engagement of targets.

Purpose of the Study:

  • To review the RECRUIT-TandAb technology.
  • To explore the therapeutic potential of RECRUIT-TandAbs in cancer treatment.

Main Methods:

  • TandAbs are designed to bind specifically to antigens on cancer cells and immune effector cells (e.g., NK cells, cytotoxic T cells).
  • The absence of an Fc domain in TandAbs mitigates certain IgG-mediated side effects.
  • Their molecular weight (~110 kDa) exceeds the renal clearance limit, enhancing pharmacokinetic properties.

Main Results:

  • RECRUIT-TandAbs facilitate targeted recruitment of immune effector cells to cancer cells.
  • This engagement leads to specific killing of cancer cells.
  • TandAbs demonstrate potential for improved safety and pharmacokinetic profiles compared to other bispecific formats.

Conclusions:

  • RECRUIT-TandAb technology represents a promising approach for cancer immunotherapy.
  • These molecules offer a unique mechanism for engaging the immune system against cancer with potential clinical advantages.

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