Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 20, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

Subcutaneous diffuse large B-cell lymphoma with intraocular involvement.

Ming Chi1, Nora Bucher, Anna Gabrielian

  • 1Department of Internal Medicine, Saint Joseph Hospital/University of Illinois at Chicago, 2900 North Lake Shore Drive, IL 60657, USA. chimingtea@gmail.com

Future Oncology (London, England)
|July 7, 2012
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quercetin alleviates thiram induced tibial dyschondroplasia in broiler chicken through modulating oxidative stress and cecal microbiota.

Frontiers in veterinary science·2026
Same author

Optimizing Sensory Experience and Aroma Profile Through Novel Blending: A Dual GC-MS/GC-IMS Approach to Characterize <i>Nitraria tangutorum</i> Bobrov.-Blended Wine.

International journal of food science·2026
Same author

[<i>In vitro</i> culture, expansion, and biological characterization of mesenchymal stem cells derived from neonatal rat liver].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University·2026
Same author

Ubenimex synergizes with the PD-L1 blockade in gastric cancer by competitively binding LAP3 with UBE3A.

Cell death & disease·2026
Same author

Interactive effects of maize straw incorporation and improved irrigation on soil physicochemical properties and microbial community structure in saline-alkaline soil.

Frontiers in microbiology·2026
Same author

Molecular subtyping and immune microenvironment heterogeneity in pediatric influenza-associated prolonged multiple organ dysfunction syndrome.

Translational pediatrics·2026
Same journal

Belantamab mafodotin, a BCMA-directed antibody-drug conjugate for multiple myeloma.

Future oncology (London, England)·2026
Same journal

Transportability of tislelizumab trial outcomes from RATIONALE-315, RATIONALE-303, and RATIONALE-312 to the European population in early-stage non-small cell lung cancer (NSCLC), advanced NSCLC and extensive-stage small cell lung cancer (ES-SCLC).

Future oncology (London, England)·2026
Same journal

Plain language summary of the MiroCIP study: how often chemotherapy-induced peripheral neuropathy happens in the first year of oxaliplatin- or taxane-based chemotherapy.

Future oncology (London, England)·2026
Same journal

Study of brentuximab vedotin combination treatment in people with early-stage Hodgkin lymphoma: a plain language summary.

Future oncology (London, England)·2026
Same journal

How enzalutamide affects sex life and how taking a break from treatment affects quality of life: a plain language summary of results from the EMBARK study in people with hormone-sensitive prostate cancer and high-risk biochemical recurrence.

Future oncology (London, England)·2026
Same journal

Physician perspectives on the decision-making process for patients with high-risk early-stage triple-negative breast cancer in a community oncology setting.

Future oncology (London, England)·2026
See all related articles

This case report details a rare instance of subcutaneous diffuse large B-cell lymphoma (DLBCL) exclusively involving the choroid. The patient achieved complete remission after systemic and intravitreal chemotherapy.

Area of Science:

  • Ophthalmology
  • Oncology
  • Hematology

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma.
  • Extranodal involvement is common in DLBCL, but subcutaneous and isolated choroidal involvement are exceptionally rare.
  • Early diagnosis and treatment are crucial for managing DLBCL.

Observation:

  • An 85-year-old female presented with a subcutaneous abdominal mass diagnosed as DLBCL.
  • She later developed decreased vision and ocular pain, with findings of a choroidal mass and vitreous seeding.
  • Vitreous aspiration confirmed intraocular DLBCL.

Findings:

  • The patient was diagnosed with stage IV subcutaneous DLBCL with isolated intraocular metastasis.
  • Treatment involved systemic and intravitreal chemotherapy.

Related Experiment Videos

Last Updated: May 20, 2026

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma
06:20

Cell-Free DNA Extraction of Vitreous and Aqueous Humor Specimens for Diagnosis and Monitoring of Vitreoretinal Lymphoma

Published on: January 12, 2024

  • Complete remission was achieved 9 months post-treatment.

    • Implications:

    • This case highlights the potential for subcutaneous DLBCL to present with isolated choroidal involvement.
    • Ophthalmologists and oncologists should consider intraocular DLBCL in patients with unexplained visual disturbances and a history of lymphoma.
    • Further research is needed to understand the mechanisms and optimal management of this rare presentation.