Related Experiment Video
Updated: May 20, 2026

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Synthesis and antibacterial activity against Clostridium difficile of novel demethylvancomycin derivatives
Si-Ji Zhang1, Qing Yang, Liang Xu
1Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai, China.
Abstract:
To explore the structure-activity relationships (SAR) of demethylvancomycin (2) and find more effective new chemical entities than known glycopeptides for the treatment of Clostridium difficile (C. difficile), 17 novel N-substituted (N-arylmethylene or -aliphatic substituents) demethylvancomycin derivatives were prepared. These analogues have been evaluated in vitro for their antibacterial activities against C. difficile and Enterococcus faecium (E. faecium). Compounds 5d, 5h, and 5i with N-arylmethylene substituents, structurally similar to Oritavancin, showed more potent antibacterial activity against C. difficile than vancomycin (1) or demethylvancomycin (2). Meanwhile, compound 5k with an undecyl side chain showed the most potent antibacterial activity against E. faecium (vancomycin-resistant strain).
Related Concept Videos
Inhibitors of Gram-positive Cell Wall Synthesis
Antimicrobial Effectiveness
Clinical Significance of Antibiotic Resistance
Inhibitors of Bacterial DNA Synthesis
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
