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Synthesis of a Microcystis aeruginosa predicted metabolite with antimalarial activity
Stella Peña1, Laura Scarone, Eduardo Manta
1Cátedra de Química Farmacéutica, DQO, Facultad de Química, UDELAR, Montevideo CP 11800, Uruguay.
Bioorganic & Medicinal Chemistry Letters
|July 7, 2012
Abstract:
The synthesis of a Microcystis aeruginosa predicted metabolite analog of aerucyclamide B was performed. This hexacyclopeptide was obtained from three heterocyclic building blocks by a convergent macrocycle-assembly methodology. The compound exhibited good in vitro antiplasmodial activity (IC(50): 0.18 μM, K1, cholorquine resistant strain).
